Like SW says... Paths to better performance vary in time and order along with aesthetic balance. I'm still learning.
A lot of understanding about what parameters are, or should be adjusted and their effects is gained from data logging and dynoing at every completed step. Not for everyone, but I like to understand what I did and not just rely completely on others, even those much more knowledgable. Also keeps me from leaving simple measures on the table and making the tuner's job harder.