I have only been tuned for about 12,000 miles but you would have to hold a gun to my head to get me to go back to stock - and it would need to be a big gun.
ZERO problems, MASSIVE performance increase, mileage at least as good and probably a little better under highway cruising conditions. Transmission behavior is far superior, too. Idle quality and overall engine smoothness is improved. My only mistake was not get the tune much sooner.