Ok, so that good run is a full multigear run... Interesting though that you are saying you dont normally see 20PSI but in the good run you are spiking that high as well. Actually, the good run looks very similar to the bad run you sent as far as load, boost, timing, etc... being a mile high above sea level explains the high WGDC numbers... air is thin up there...
I would agree with the SHOdded on this one, looks like the winter gas is killing your fuel pressure and giving you knock issues now.
Your tuner is giving you BIG boost and little to no timing advance.. probably much less than stock? I have not seen timing that low on a Ecoboost datalog before, but to be fair, I don't normally look at the F150 datalogs...
I would run that bad boy stock until the summer blends come back IMHO