There are 3 vehicles that have been on the road with piggybacks, mine with splitsec ECU which sucked horribly, Todd and Jacob's SHO which both have ProEFI 48 which work awesome.
The ProEFI48 requires you to tap into the factory harness for ignition timing, install 2 additional WBO2 and a 3 bar MAP sensor (they use a 5 bar). The piggyback controls the aux fuel injectors only and it's a self tuning ECU like the stock ECU. To simplify what is being done both are commanded to hit say .74 LAMBDA, the only time the ProEFI ECU does anything is above X PSI, below that factory ECU is doing all of the fueling.
If you want additional information contact Erick at Leading Edge Tuning.