The need to shutoff the rear O2 sensors is ONLY if you don't have a catted downpipe with the newest hi-flow cats (Magnaflow) in them. If the tune is adjusted for the presence of aftermarket hi-flow downpipes, and you don't have them installed yet, the vehicle may feel boggy in the lower rev range, where the hi-flow dp's make the most difference.
So yeah, run a non-dp tune if you don't have the dp's installed yet. But I don't think it will cause any damage if that's what you are asking.