I run 18"s on my Flex. They are smaller diameter 27" vs 29" and the wheel/tire combo weigh between 44 and 48 lbs. I have 2 sets of aftermarket wheels/tires. Haven't weighed my Michelin Pilot Super Sports since they are nearly worn out, but my Conti DW's went from 48 lbs down to 44 lbs after 25K, which is what the Pilot's on TSW Interlagos weighed new. I dropped nearly 80lbs of unsprung weight. My mileage hasn't suffered at all simply because the engine doesn't work as hard speeding up and slowing down the lower rotating mass weight. Braking is much better, especiall with my Stop Tech front pads. Acceleration is better due to lower axle ratio and the lower weight. Have the equivalent of a 3.40 axle ratio.
This is just my opinion... but I am going to continue with these setups when I get new shoes.